Molecular Imaging Core

The Molecular Imaging Core provides comprehensive services for non-invasive imaging with a 7 Tm Magnetic Resonance Imager (MRI) and a MicroPET (Positron Emission Tomography). These instruments can be used to image small animals, biological tissues, phantoms, appendages of human subjects, and many other samples. An on-site cyclotron and a fully staffed radiochemistry laboratory provide a wide range of standard radiolabeled PET imaging probes and can help develop and produce custom probes.

Additional Information
Services Provided
Instrumentation
Fees and Terms of Service
Contact Information

Overview of Core Services

 

Services Provided

  • Consultation on the development of imaging protocols, including selection of imaging modalities and techniques most appropriate for a project
  • Assistance with experimental design and submission to the Institutional Animal Care and Use Committee
  • Design and production of standard (e.g., C-11, F-18, N-13, O-11, I-124), novel and custom PET markers
  • Expert guidance to facilitate synthesis of new radiopharmaceuticals, contrast agents and specialized techniques
  • Preparation and monitoring of animals prior to and during imaging Quantitative analyses of images obtained with the 7 T MRI, MicroPET and other devices 

Instrumentation

Siemens Focus 220 MicroPET:  A high resolution analytical imaging scintillation PET camera that uses compounds labeled with positron emitting radioisotopes as molecular probes to image and measure biochemical processes in vivo

 

 


 

Bruker PharmaScan 7T MRI: A high-field MRI equipped with multiple gradient sets specifically for in vivo microimaging applications. It has broadband capabilities for multinuclear imaging and spectroscopy applications (e.g., 1H, 31P, 15N, 13C, 19F). The system is capable of cardiac/respiratory gating/monitoring to limit the negative effects of motion on image quality. This feature is critical for imaging animals with high respiration and/or heart rates.


 

Siemens Eclipse RD 11 MeV Cyclotron: Produces radioactive isotopes to label drugs, metabolites, biochemicals, signal transduction agents, liposomes, nanoparticles and other carriers to image and measure molecular and metabolic events, pharmacokinetics, biochemistry, etc. in vivo using the MicroPET. 

 


 

Radiochemistry Laboratory: Couples the radioisotopes to the desired PET-probes. More than 30 standard PET-probes can be produced with suitable notice (usually two weeks). Novel and customized PET probes can also be designed and produced.


 

Image Analysis Laboratory:  equipped for computer-based, quantitative analyses of images obtained with the 7 T MRI and MicroPET; and for images obtained with other devices at UAMS.


 

Fees and Terms of Service

Imaging Fee:  $150/hour for PET and MRI

Analysis Fee:  $150/hour

Design and production of PET markers varies

Contact Information

Molecular Imaging Core
Winthrop P. Rockefeller Cancer Institute, Walker Tower, Basement
4301 West Markham Street
Mail Slot 556
Little Rock, AR 72205
researchimaging@uams.edu 

Michael Borrelli, Ph.D., Director
Department of Radiology
UAMS College of Medicine
mjborelli@uams.edu
501-526-5897

Terri Alpe, B.S., C.N.M.T., Imaging Specialist
alpeterril@uams.edu
501-686-8875