Electronic Health Care Data for Research



Enterprise Data Warehouse

The UAMS Enterprise Data Warehouse integrates clinical, basic science and other data for research and quality reporting. The warehouse receives nightly updates from EpicCare and contains historical data from four previously used clinical source systems (Medipac, Centricity, Sunrise, SoftLab).

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Request data from the enterprise data warehouse

Types of Data
  • Demographics
  • Diagnoses (ICD-9 – CCS)
  • Labs
  • Medications
  • Procedures
  • Vaccinations
  • Visit Type
  • Vital Signs
  • Hospitalizations
    • Length of stay
    • Admission Type
    • Medicare Severity Diagnosis Related Groups (MS-DRG)
    • Discharge Disposition


Informatics for Integrating Biology and the Bedside (i2b2)

i2b2 is an open-source platform for retrieving de-identified data from the UAMS Enterprise Data Warehouse. i2b2 was designed primarily for cohort identification, allowing users to perform queries to determine the existence of a set of patients meeting certain inclusion or exclusion criteria (e.g., how many patients are on medication X; how many are adhering to evidence-based guideline Y).

i2b2 can be used to perform self-service queries of de-identified data for HIPAA-compliant cohort discovery and hypothesis testing. Investigators and research staff may logon to i2b2 using their UAMS userid and password.

View i2b2 Instructional Video Access i2b2

Access i2b2 (from within UAMS network)

Honest Broker System

The Translational Research Institute (TRI) and the Division of Biomedical Informatics established an honest broker system to complement the UAMS Enterprise Data Warehouse. An honest broker is a neutral intermediary (person or system) between a researcher and the individual whose tissue and data are being studied and the healthcare provider who obtained the tissue and data for patient care purposes. The honest broker collects and collates pertinent information regarding the tissue, data, biological specimens, and/or images, replaces identifiers with a code, and releases only coded information to the researcher.

TRI, in collaboration with Information Technology Security, the Institutional Review Board (IRB) and HIPAA office, established the Honest Broker Certification for Research Policy required to initiate the honest broker system.

Honest Broker Certification Application

Frequently Asked Questions

How does the honest broker system benefit researchers?
What sources of data can be accessed through an honest broker?
What types of data requests can an honest broker facilitate?
Can honest brokers pull more than data?
How is protected health information safeguarded?
Will data be anonymized?
Will an honest broker be required to sign a business associate agreement (BAA)?
Are honest brokers affiliated with the HIPAA Office?

How does the honest broker system benefit researchers? Researchers can use an honest broker to access multiple sources of clinical data. The honest broker can perform queries of the data warehouse per a researcher’s request and provide a limited data set in which certain protected health information is de-identified.

An IRB-certified honest broker system can review your IRB protocol to ensure that it complies with its procedures and that it has the ability to fulfill your requirements. Once you and the honest broker are in agreement, the honest broker will provide a certification to be submitted along with your IRB protocol. Having an honest broker as part of your protocol will signify to the IRB that you are following best practices for use of clinical data in your research.

What sources of data can be accessed through an honest broker? Only information in the data warehouse will be accessible at first. We envision the scope of the honest broker system at UAMS will expand to include other data, tissue and image repositories. Initially, the data warehouse will include admissions, discharge, transfer (ADT); diagnoses and procedures; medications and vaccinations; allergies; and labs. Eventually, caTissue, caArray and other source systems will be incorporated.

What types of data requests can an honest broker facilitate? Tissue bank; pathology and laboratory information services; radiation oncology systems; outpatient systems and hospital information systems; clinical trials-related applications; cancer registry applications (OncoLog is UAMS software vendor); radiology information systems and image archiving; communications systems transcription systems; and trauma registry applications.

Can honest brokers pull more than data? Yes, depending on the honest broker system, biological specimens and images may also be available.

How is protected health information safeguarded? The honest broker provides investigators with a non-anonymized, limited data set. This means 16 of the 18 HIPAA identifiers are removed and replaced with a tag. The honest broker maintains a link so data is not completely anonymized. The honest broker also ensures that researchers have an approved IRB protocol before releasing data, and certifies during IRB protocol submission that the data will be provided according to their IRB-certified and approved procedures.

Will data be anonymized? No, data will not be completely anonymized. If data were completely anonymized, re-identification would not be possible and an honest broker would not be necessary (if no data link is retained, the Common Rule does not apply).

Will an honest broker be required to sign a business associate agreement (BAA)? For UAMS employees, no, a BAA is not necessary because an honest broker must be an agent of the organization that owns the data, images and biological specimens. At UAMS the honest broker falls under the covered entity umbrella. For the time being, we do not envision making data available outside UAMS. In the future, if UAMS does choose to make data available to non-UAMS employees, then honest brokers outside UAMS would have to submit a BAA.

Are honest brokers affiliated with the HIPAA Office? No, honest brokers are not HIPAA officers or IRB/hospital compliance policy setters. Honest brokers must abide by federal policy regulations (45 CFR 46.116.d) and the HIPAA Privacy Rule, but they are not responsible for conveying or interpreting policies.